≡

Septin 9 (SEPT9)

[Edit]

MSF; MSF1; NAPB; PNUTL4; SINT1; Septin D1; MLL Septin-Like Fusion; MLL septin-like fusion protein MSF-A; Ovarian/Breast septin

Septin 9 (SEPT9)
CCC F869
HGNC 7323
MGI 1858222
PubMed 10339604
RGD 708523
UniProt Q9UHD8
Wiki SEPT9
SEPT9 is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.MSF encodes a putative protein of 568 amino acids with a predicted molecular mass of about 63 kD. Northern blot analysis revealed a major 4-kb transcript that was expressed ubiquitously, a 1.7-kb transcript that was found in most tissues, and a 3-kb transcript that was found only in hematopoietic tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Septin 9 (SEPT9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Septin 9 (SEPT9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Septin 9 (SEPT9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Septin 9 (SEPT9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Septin 9 (SEPT9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Septin 9 (SEPT9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Septin 9 (SEPT9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Septin 9 (SEPT9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Septin 9 (SEPT9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Septin 9 (SEPT9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Septin 9 (SEPT9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Septin 9 (SEPT9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Septin 9 (SEPT9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Septin 9 (SEPT9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Septin 9 (SEPT9) ELISA Kit Customized Service Offer
  1. "MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)."Proc. Natl. Acad. Sci. U.S.A. 96:6428-6433(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors."Cancer Res. 60:4729-4734(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic and expression analyses of alternatively spliced transcripts of the MLL septin-like fusion gene (MSF) that map to a 17q25 region of loss in breast and ovarian tumors."Genomics 63:165-172(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3."Oncogene 20:5930-5939(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11."J. Biol. Chem. 279:55895-55904(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Expression profiling the human septin gene family."J. Pathol. 206:269-278(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin."Oncogene 24:65-76(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Possible role of Rho/Rhotekin signaling in mammalian septin organization."Oncogene 24:7064-7072(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  14. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  15. "SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling."Hum. Mutat. 28:1005-1013(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin."Mamm. Genome 18:796-807(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Septins regulate bacterial entry into host cells."PLoS ONE 4:E4196-E4196(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Mutations in SEPT9 cause hereditary neuralgic amyotrophy." Nat. Genet. 37:1044-1046(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Dysmorphic syndrome of hereditary neuralgic amyotrophy associated with a SEPT9 gene mutation -- a family study."Clin. Genet. 74:279-283(2008) [PubMed] [Europe PMC] [Abstract]
  29. "SEPT9 gene sequencing analysis reveals recurrent mutations in hereditary neuralgic amyotrophy."Neurology 72:1755-1759(2009) [PubMed] [Europe PMC] [Abstract]