Secreted Frizzled Related Protein 1 (SFRP1)
[Edit]FRP1; FRP; FRP-1; FrzA; SARP2; Secreted apoptosis-related protein 2
-95880.jpg)
Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP1 and SFRP5 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP1 is expressed in several human tissues, with the highest levels in heart.
SFRP1 is a 35 kDa prototypical member of the SFRP family. It acts as a biphasic modulator of Wnt signaling, counteracting Wnt-induced effects at high concentrations and promoting them at lower concentrations. It is located in a chromosomal region (8p12-p11.1) that is frequently deleted in breast cancer and is thought to harbour a tumor suppressor gene.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPF880Hu01 | Recombinant Secreted Frizzled Related Protein 1 (SFRP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAF880Hu01 | Polyclonal Antibody to Secreted Frizzled Related Protein 1 (SFRP1) | WB; IHC; ICC; IP. |
| MAF880Hu21 | Monoclonal Antibody to Secreted Frizzled Related Protein 1 (SFRP1) | WB,IHC | |
| MAF880Hu22 | Monoclonal Antibody to Secreted Frizzled Related Protein 1 (SFRP1) | WB; IHC; ICC; IP. | |
| MAF880Hu23 | Monoclonal Antibody to Secreted Frizzled Related Protein 1 (SFRP1) | WB; IHC; ICC; IP. | |
| MAF880Hu24 | Monoclonal Antibody to Secreted Frizzled Related Protein 1 (SFRP1) | WB; IHC; ICC; IP. | |
| MAF880Hu25 | Monoclonal Antibody to Secreted Frizzled Related Protein 1 (SFRP1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEF880Hu | ELISA Kit for Secreted Frizzled Related Protein 1 (SFRP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPF880Mu01 | Recombinant Secreted Frizzled Related Protein 1 (SFRP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPF880Mu02 | Recombinant Secreted Frizzled Related Protein 1 (SFRP1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAF880Mu01 | Polyclonal Antibody to Secreted Frizzled Related Protein 1 (SFRP1) | WB; IHC; ICC; IP. |
| LAF880Mu71 | Biotin-Linked Polyclonal Antibody to Secreted Frizzled Related Protein 1 (SFRP1) | WB; IHC; ICC. | |
| LAF880Mu81 | FITC-Linked Polyclonal Antibody to Secreted Frizzled Related Protein 1 (SFRP1) | WB; IHC; ICC; IF. | |
| PAF880Mu02 | Polyclonal Antibody to Secreted Frizzled Related Protein 1 (SFRP1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEF880Mu | ELISA Kit for Secreted Frizzled Related Protein 1 (SFRP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
- "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action."Proc. Natl. Acad. Sci. U.S.A. 94:6770-6775(1997) [PubMed] [Europe PMC] [Abstract]
- "SARPs: a family of secreted apoptosis-related proteins."Proc. Natl. Acad. Sci. U.S.A. 94:13636-13641(1997) [PubMed] [Europe PMC] [Abstract]
- "Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors."Int. J. Cancer 78:95-99(1998) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules."J. Biol. Chem. 277:5134-5144(2002) [PubMed] [Europe PMC] [Abstract]
- "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling."J. Biol. Chem. 274:16180-16187(1999) [PubMed] [Europe PMC] [Abstract]
- "Secreted frizzled related protein 1 is overexpressed in uterine leiomyomas, associated with a high estrogenic environment and unrelated to proliferative activity."J. Clin. Endocrinol. Metab. 87:1729-1736(2002) [PubMed] [Europe PMC] [Abstract]