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Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2)

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SREBP2; bHLHd2; Class D basic helix-loop-helix protein 2; Sterol regulatory element-binding transcription factor 2

Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2)
CCC F902
HGNC 11290
MGI 107585
PubMed 23625920
RGD 1307751
UniProt Q12772
Wiki SREBF2
SREBF2 encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
SCAP escorts SREBPs from the endoplasmic reticulum (ER) to the Golgi, where SREBPs are cleaved by site-1 protease (S1P). The authors showed that sterols block this transport and abolish cleavage. Relocating active S1P from Golgi to ER by treating cells with brefeldin A or by fusing the ER retention signal KDEL to S1P obviated the SCAP requirement and rendered cleavage insensitive to sterols.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) ELISA Kit Customized Service Offer
  1. "SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element."Proc. Natl. Acad. Sci. U.S.A. 90:11603-11607(1993) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene."Cell 75:187-197(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane."J. Biol. Chem. 271:10379-10384(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins."Proc. Natl. Acad. Sci. U.S.A. 93:5437-5442(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning."J. Biol. Chem. 273:17801-17809(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease."Proc. Natl. Acad. Sci. U.S.A. 97:5123-5128(2000) [PubMed] [Europe PMC] [Abstract]
  10. "The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage."J. Biol. Chem. 284:28995-29004(2009) [PubMed] [Europe PMC] [Abstract]
  11. "The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor."Science 302:1571-1575(2003) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]