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Sperm Associated Antigen 5 (SPAG5)

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DEEPEST; MAP126; hMAP126; Deepest; Mitotic Spindle Coiled-Coil Related Protein; Astrin; Mitotic Spindle Associated Protein p126

Sperm Associated Antigen 5 (SPAG5)
CCC F905
HGNC 13452
MGI 1927470
PubMed 23351521
RGD 620152
UniProt Q96R06
Wiki SPAG5
SPAG5 encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon.Cytoplasm. Spindle. In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Detected on kinetochores of chromosomes that have congressed. Necessary for normal spindle formation during mitosis.Homodimer, with a globular head domain and a long stalk. Homo-oligomer; the globular head domains associate, resulting in aster-like structures. Binds to microtubules in the mitotic spindle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Associated Antigen 5 (SPAG5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Associated Antigen 5 (SPAG5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Associated Antigen 5 (SPAG5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Associated Antigen 5 (SPAG5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Associated Antigen 5 (SPAG5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Associated Antigen 5 (SPAG5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Associated Antigen 5 (SPAG5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Associated Antigen 5 (SPAG5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Associated Antigen 5 (SPAG5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Associated Antigen 5 (SPAG5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Associated Antigen 5 (SPAG5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Associated Antigen 5 (SPAG5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Associated Antigen 5 (SPAG5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Associated Antigen 5 (SPAG5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Associated Antigen 5 (SPAG5) ELISA Kit Customized Service Offer
  1. "Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein."Proc. Natl. Acad. Sci. U.S.A. 98:14434-14439(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins."Biochem. Biophys. Res. Commun. 287:116-121(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The mitotic-spindle-associated protein astrin is essential for progression through mitosis."J. Cell Sci. 115:4053-4059(2002) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity."J. Cell Biol. 178:345-354(2007) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Astrin regulates Aurora-A localization."Biochem. Biophys. Res. Commun. 370:213-219(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin."J. Biol. Chem. 283:2454-2464(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint."Cell Cycle 8:628-638(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment."J. Cell Biol. 192:959-968(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells."Cell 154:859-874(2013) [PubMed] [Europe PMC] [Abstract]