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Syntaxin Binding Protein 3 (STXBP3)

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PSP; MUNC18-3; MUNC18C; UNC-18C; Platelet Sec1 protein; Protein unc-18 homolog 3

Syntaxin Binding Protein 3 (STXBP3)
CCC F923
HGNC 11446
MGI 107362
PubMed 21897333
RGD 619968
UniProt O00186
Wiki STXBP3
The deduced 592-amino acid protein has a calculated molecular mass of 68 kD and contains sequence motifs for protein kinase C (PKC) and casein kinase II phosphorylation. STXBP3 was predicted to be a hydrophilic protein. Northern blot analysis detected a STXBP3 transcript of about 2.7 kb in 3 megakaryocytic cell lines. Western blot analysis detected a 68-kD protein in platelet detergent extracts. STXBP3 partitioned with the cytosolic platelet fraction, with small amounts in the particulate or membrane fraction.The deduced 592-amino acid protein lacks hydrophobic sequences, suggesting that it is an intracellular cytosolic protein. Human and mouse STXBP3 share 91% amino acid identity. Northern blot analysis of mouse tissues detected a 2.8-kb transcript in all tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Syntaxin Binding Protein 3 (STXBP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Syntaxin Binding Protein 3 (STXBP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Syntaxin Binding Protein 3 (STXBP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Syntaxin Binding Protein 3 (STXBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Syntaxin Binding Protein 3 (STXBP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Syntaxin Binding Protein 3 (STXBP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Syntaxin Binding Protein 3 (STXBP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Syntaxin Binding Protein 3 (STXBP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Syntaxin Binding Protein 3 (STXBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Syntaxin Binding Protein 3 (STXBP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Syntaxin Binding Protein 3 (STXBP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Syntaxin Binding Protein 3 (STXBP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Syntaxin Binding Protein 3 (STXBP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Syntaxin Binding Protein 3 (STXBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Syntaxin Binding Protein 3 (STXBP3) ELISA Kit Customized Service Offer
  1. "A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants."J. Neurosci. 16:6695-6702(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion."Blood 93:2617-2626(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]