Stathmin 2 (STMN2)

Superior cervical ganglion-10 is a neuronal growth-associated protein that shares significant amino acid sequence similarity with the phosphoprotein stathmin.

The predicted amino acid sequences of SCG10 in the 2 species differ by a single residue . The mouse Scgn10 transcription unit spans at least 30 kb, while the stathmin gene is 6 kb long. Both genes have 5 exons. Southern blot analysis indicated that Scgn10 is encoded by a single gene in the mouse that is linked to Il7 in the proximal region of chromosome 3. Okazaki et al. (1993) suggested that in contrast to the more broadly expressed stathmin gene, the neuron-specific SCG10 gene may have evolved by duplication and acquisition of a tissue-specific promoter.