≡

Spectrin Beta, Non Erythrocytic 1 (SPTbN1)

[Edit]

ELF; SPTB2; BetaSpII; Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1

Spectrin Beta, Non Erythrocytic 1 (SPTbN1)
CCC F948
HGNC 11275
MGI 98388
PubMed 23460728
RGD 727922
UniProt Q01082
Wiki SPTBN1
SPTbN1 is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.The deduced 2,364-amino acid SPTBN1 protein has a calculated molecular mass of 274.5 kD. Like SPTB, SPTBN1 has a putative N-terminal actin-binding domain, a central tandem series of 17 repeats of a 106-amino acid motif, and a C-terminal domain. Northern blot analysis of several rat tissues detected highest expression in lung, followed by kidney, brain, thymus, heart, and liver. Western blot analysis of cytosolic and membrane fractions of rat tissues revealed Sptbn1 proteins of 275 to 285 kD that were enriched in membrane fractions of brain, kidney, and lung.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spectrin Beta, Non Erythrocytic 1 (SPTbN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spectrin Beta, Non Erythrocytic 1 (SPTbN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spectrin Beta, Non Erythrocytic 1 (SPTbN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spectrin Beta, Non Erythrocytic 1 (SPTbN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spectrin Beta, Non Erythrocytic 1 (SPTbN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spectrin Beta, Non Erythrocytic 1 (SPTbN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spectrin Beta, Non Erythrocytic 1 (SPTbN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spectrin Beta, Non Erythrocytic 1 (SPTbN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spectrin Beta, Non Erythrocytic 1 (SPTbN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spectrin Beta, Non Erythrocytic 1 (SPTbN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spectrin Beta, Non Erythrocytic 1 (SPTbN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spectrin Beta, Non Erythrocytic 1 (SPTbN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spectrin Beta, Non Erythrocytic 1 (SPTbN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spectrin Beta, Non Erythrocytic 1 (SPTbN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spectrin Beta, Non Erythrocytic 1 (SPTbN1) ELISA Kit Customized Service Offer
  1. "Characterization of human brain cDNA encoding the general isoform of beta-spectrin."J. Biol. Chem. 267:18715-18722(1992) [PubMed] [Europe PMC] [Abstract]
  2. "A novel isoform of beta-spectrin II localizes to cerebellar Purkinje-cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin."J. Mol. Neurosci. 17:59-70(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning of a portion of the chromosomal gene and cDNA for human beta-fodrin, the nonerythroid form of beta-spectrin."Genomics 17:287-293(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a novel C-terminal variant of betaII spectrin: two isoforms of betaII spectrin have distinct intracellular locations and activities."J. Cell Sci. 113:2023-2034(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes."J. Biol. Chem. 279:40185-40193(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  21. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  22. "A conserved sequence in CAMSAP1 (calmodulin regulated spectrin-associated protein 1) links its interaction with spectrin and calmodulin to neurite outgrowth."J. Neurochem. 128:391-402(2014) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of a calponin homology domain."Nat. Struct. Biol. 4:175-179(1997) [PubMed] [Europe PMC] [Abstract]
  25. "Structural comparisons of calponin homology domains: implications for actin binding."Structure 6:1419-1431(1998) [PubMed] [Europe PMC] [Abstract]