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Nesprin 2 (Nesp2)

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SYNE2; NUA; NUANCE; SYNE-2; Synaptic nuclear envelope protein 2; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein

Nesprin 2 (Nesp2)
CCC F952
HGNC 17084
MGI 2449316
PubMed 10231032
RGD 1305248
UniProt Q8WXH0
Wiki SYNE2

SYNE2 is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. SYNE2 contains multiple spectrin repeats and a 60-amino acid C-terminal region homologous to the Drosophila protein Klarsicht. RT-PCR analysis showed low to moderate expression of 2 SYNE2 splice variants in most tissues examined, including skeletal and cardiac muscle, kidney, liver, pancreas, and placenta, and indicated that alternative splicing patterns are conserved between SYNE1 and SYNE2.Nesprin-2-gamma also has a bipartite nuclear localization signal and a leucine zipper motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF952Hu01 Recombinant Nesprin 2 (Nesp2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF952Hu01 Polyclonal Antibody to Nesprin 2 (Nesp2) WB
MAF952Hu21 Monoclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IP.
Assay Kits SEF952Hu ELISA Kit for Nesprin 2 (Nesp2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nesprin 2 (Nesp2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nesprin 2 (Nesp2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nesprin 2 (Nesp2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nesprin 2 (Nesp2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nesprin 2 (Nesp2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nesprin 2 (Nesp2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nesprin 2 (Nesp2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nesprin 2 (Nesp2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nesprin 2 (Nesp2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nesprin 2 (Nesp2) ELISA Kit Customized Service Offer
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  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
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  19. "Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes."J. Biol. Chem. 285:3487-3498(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement."Science 329:956-959(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins."PLoS ONE 8:E63633-E63633(2013) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Nesprins: tissue-specific expression of epsilon and other short isoforms."PLoS ONE 9:E94380-E94380(2014) [PubMed] [Europe PMC] [Abstract]
  27. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  28. "Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity."Hum. Mol. Genet. 16:2816-2833(2007) [PubMed] [Europe PMC] [Abstract]