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Nesprin 1 (Nesp1)

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SYNE1; C6orf98; 8B; MYNE1; CPG2; SCAR8; ARCA1; Enaptin; Myocyte nuclear envelope protein 1; Nuclear envelope spectrin repeat protein 1; Synaptic nuclear envelope protein 1

Nesprin 1 (Nesp1)
CCC F953
HGNC 17089
MGI 1927152
PubMed 11792814
RGD 620546
UniProt Q8NF91
Wiki Nesprin-1
Enaptin is a nuclear envelope protein found in human myocytes and synapses, which is made up of 8,797 amino acids. Post-translational amino acid modifications can be possible. Enaptin is involved in the maintenance of nuclear organization and structural integrity, tethering the cell nucleus to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm.
Enaptin has a remarkable structure with a coiled alpha-helical region and a large beta-sheet region in the upper part and at least four alpha-helices spliced together, indicating the similarity with collagen. The structural integrity of Enaptin can be shown by determining whether the protein forms a condensed supramolecule.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF953Hu01 Recombinant Nesprin 1 (Nesp1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF953Hu01 Polyclonal Antibody to Nesprin 1 (Nesp1) WB; IHC; ICC; IP.
MAF953Hu21 Monoclonal Antibody to Nesprin 1 (Nesp1) WB; IHC; ICC; IP.
Assay Kits SEF953Hu ELISA Kit for Nesprin 1 (Nesp1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nesprin 1 (Nesp1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nesprin 1 (Nesp1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nesprin 1 (Nesp1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nesprin 1 (Nesp1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nesprin 1 (Nesp1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nesprin 1 (Nesp1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nesprin 1 (Nesp1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nesprin 1 (Nesp1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nesprin 1 (Nesp1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nesprin 1 (Nesp1) ELISA Kit Customized Service Offer
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  2. "The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300."Genomics 80:473-481(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C."J. Cell Sci. 115:61-70(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas."Int. J. Cancer 123:2048-2056(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton."Exp. Cell Res. 295:330-339(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Golgi localization of Syne-1."Mol. Biol. Cell 14:2410-2424(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  11. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
  14. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro."FEBS Lett. 525:135-140(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Identification and characterization of GSRP-56, a novel Golgi-localized spectrin repeat-containing protein."Exp. Cell Res. 312:3152-3164(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia."Nat. Genet. 39:80-85(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness."Exp. Cell Res. 314:1892-1905(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Cytoskeletal interactions at the nuclear envelope mediated by nesprins."Int. J. Cell Biol. 2012:736524-736524(2012) [PubMed] [Europe PMC] [Abstract]
  23. "Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins."PLoS ONE 8:E63633-E63633(2013) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  26. "Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity."Hum. Mol. Genet. 16:2816-2833(2007) [PubMed] [Europe PMC] [Abstract]
  27. "Identification of pathogenic gene variants in small families with intellectually disabled siblings by exome sequencing." J. Med. Genet. 50:802-811(2013) [PubMed] [Europe PMC] [Abstract]