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Melittin (MELT)

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Melittin (MELT)
CCC F956
PubMed 18506888
UniProt P01501
Wiki Melittin
Melittin is the principal active component of bee venom (apitoxin), and is a powerful stimulator of phospholipase A2. Melittin also exhibits potent anti-microbial activity.Melittin has also been shown to kill the yeast Candida albicans and to suppress Mycoplasma hominis and Chlamydia trachomatis infections. Melittin: Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. It increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange. It acts synergistically with phospholipase A2.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Melittin (MELT) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Melittin (MELT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melittin (MELT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Melittin (MELT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Melittin (MELT) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence of cloned cDNA coding for honeybee prepromelittin."Eur. J. Biochem. 135:123-126(1983) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence analysis of melittin from tryptic and peptic degradation products."Hoppe-Seyler's Z. Physiol. Chem. 348:37-50(1967) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a novel melittin isoform from Africanized Apis mellifera venom."Peptides 31:1473-1479(2010) [PubMed] [Europe PMC] [Abstract]
  4. "Africanized honey bee (Apis mellifera) venom profiling: Seasonal variation of melittin and phospholipase A(2) levels."Toxicon 56:355-362(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Haemolytic activity and action on the surface tension of aqueous solutions of synthetic melittins and their derivatives."Experientia 27:764-765(1971) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation and structure of N 1-formyl melittin."Experientia 27:765-767(1971) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation and structures of grammistins, peptide toxins from the skin secretion of the soapfish Grammistes sexlineatus."Toxicon 38:91-103(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The structure of melittin. II. Interpretation of the structure."J. Biol. Chem. 257:6016-6022(1982) [PubMed] [Europe PMC] [Abstract]
  9. , Submitted (JUN-1998) to the PDB data bank
  10. "The actions of melittin on membranes."Biochim. Biophys. Acta 1031:143-161(1990) [PubMed] [Europe PMC] [Abstract]