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Protoporphyrinogen Oxidase (PPOX)

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VP; PPO; V290M; Variegate Porphyria

Protoporphyrinogen Oxidase (PPOX)
CCC F960
HGNC 9280
MGI 104968
PubMed 9554235
RGD 1310543
UniProt P50336
Wiki PPOX
PPOX is a human gene that produces an enzyme called protoporphyrinogen oxidase. This enzyme is responsible for the seventh step in heme production. Heme is the portion of hemoglobin that carries oxygen in the blood from the lungs to the rest of the body. Each of the steps in heme production is controlled by a separate gene. Protoporphyrinogen oxidase removes hydrogen atoms from protoporphyrinogen IX (the product of the sixth step in the production of heme) to form protoporphyrin IX. One additional enzyme must modify protoporphyrin IX before it becomes heme.This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. This protein is a flavoprotein associated with the outer surface of the inner mitochondrial membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF960Hu01 Recombinant Protoporphyrinogen Oxidase (PPOX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF960Hu01 Polyclonal Antibody to Protoporphyrinogen Oxidase (PPOX) WB; IHC; ICC; IP.
MAF960Hu21 Monoclonal Antibody to Protoporphyrinogen Oxidase (PPOX) WB; IHC; ICC; IP.
Assay Kits SEF960Hu ELISA Kit for Protoporphyrinogen Oxidase (PPOX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protoporphyrinogen Oxidase (PPOX) Recombinant Protein Customized Service Offer
Antibodies PAF960Mu01 Polyclonal Antibody to Protoporphyrinogen Oxidase (PPOX) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protoporphyrinogen Oxidase (PPOX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protoporphyrinogen Oxidase (PPOX) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF960Ra01 Recombinant Protoporphyrinogen Oxidase (PPOX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF960Ra01 Polyclonal Antibody to Protoporphyrinogen Oxidase (PPOX) WB; IHC; ICC; IP.
MAF960Ra21 Monoclonal Antibody to Protoporphyrinogen Oxidase (PPOX) WB; IHC; ICC; IP.
Assay Kits SEF960Ra ELISA Kit for Protoporphyrinogen Oxidase (PPOX) Enzyme-linked immunosorbent assay for Antigen Detection.
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  27. "Modulation of penetrance by the wild-type allele in dominantly inherited erythropoietic protoporphyria and acute hepatic porphyrias."Hum. Genet. 114:256-262(2004) [PubMed] [Europe PMC] [Abstract]
  28. "A Chilean boy with severe photosensitivity and finger shortening: the first case of homozygous variegate porphyria in South America."Br. J. Dermatol. 154:368-371(2006) [PubMed] [Europe PMC] [Abstract]
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  30. "Genetic studies in variegate porphyria in Spain. Identification of gene mutations and family study for carrier detection."J. Eur. Acad. Dermatol. Venereol. 20:974-979(2006) [PubMed] [Europe PMC] [Abstract]
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  32. "Novel human pathological mutations. Gene symbol: PPOX. Disease: porphyria, variegate."Hum. Genet. 122:417-417(2007) [PubMed] [Europe PMC] [Abstract]
  33. "Genetic and biochemical studies in Argentinean patients with variegate porphyria."BMC Med. Genet. 9:54-54(2008) [PubMed] [Europe PMC] [Abstract]
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  36. "Homozygous variegate porphyria presenting with developmental and language delay in childhood."Clin. Exp. Dermatol. 38:737-740(2013) [PubMed] [Europe PMC] [Abstract]