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Deleted In Azoospermia 1 (DAZ1)

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DAZ; SPGY; DAZ1; pDP1680; pDP1681

Deleted In Azoospermia 1 (DAZ1)
CCC F967
HGNC 2682
PubMed 11870237
UniProt Q9NQZ3
Wiki DAZ1
DAZ1 is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to pre-meiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deleted In Azoospermia 1 (DAZ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deleted In Azoospermia 1 (DAZ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deleted In Azoospermia 1 (DAZ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deleted In Azoospermia 1 (DAZ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deleted In Azoospermia 1 (DAZ1) ELISA Kit Customized Service Offer
  1. "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Nature 423:825-837(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome."Genomics 67:256-267(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1."Genomics 65:266-273(2000) [PubMed] [Europe PMC] [Abstract]
  5. "DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice."Biol. Reprod. 63:1490-1496(2000) [PubMed] [Europe PMC] [Abstract]
  6. "In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein."Gene 252:119-126(2000) [PubMed] [Europe PMC] [Abstract]
  7. "A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans."Proc. Natl. Acad. Sci. U.S.A. 98:7414-7419(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins."Proc. Natl. Acad. Sci. U.S.A. 100:538-543(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Polymorphic DAZ gene family in polymorphic structure of AZFc locus: artwork or functional for human spermatogenesis?"APMIS 111:115-127(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome."J. Clin. Endocrinol. Metab. 85:4069-4073(2000) [PubMed] [Europe PMC] [Abstract]
  11. "High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia."Mol. Hum. Reprod. 8:286-298(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Partial DAZ deletions in a family with five infertile brothers."Fertil. Steril. 79:1652-1655(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Copy number of DAZ genes in infertile men."Fertil. Steril. 84:1522-1525(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Restricted expression of the human DAZ protein in premeiotic germ cells."Hum. Reprod. 23:1280-1289(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Polymorphic expression of DAZ proteins in the human testis."Hum. Reprod. 24:1507-1515(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation."Nature 462:222-225(2009) [PubMed] [Europe PMC] [Abstract]