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Deleted In Azoospermia Like Protein (DAZL)

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DAZH; DAZL1; DAZLA; SPGYLA; DAZ-like autosomal; Deleted in azoospermia-like 1; SPGY-like-autosomal

Deleted In Azoospermia Like Protein (DAZL)
CCC F972
HGNC 2685
MGI 1342328
PubMed 19865085
RGD 1591714
UniProt Q92904
Wiki DAZL
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females.
Deleted In Azoospermia Like Protein is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deleted In Azoospermia Like Protein (DAZL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deleted In Azoospermia Like Protein (DAZL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deleted In Azoospermia Like Protein (DAZL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deleted In Azoospermia Like Protein (DAZL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deleted In Azoospermia Like Protein (DAZL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deleted In Azoospermia Like Protein (DAZL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deleted In Azoospermia Like Protein (DAZL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deleted In Azoospermia Like Protein (DAZL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deleted In Azoospermia Like Protein (DAZL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deleted In Azoospermia Like Protein (DAZL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deleted In Azoospermia Like Protein (DAZL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deleted In Azoospermia Like Protein (DAZL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deleted In Azoospermia Like Protein (DAZL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deleted In Azoospermia Like Protein (DAZL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deleted In Azoospermia Like Protein (DAZL) ELISA Kit Customized Service Offer
  1. "The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned."Nat. Genet. 14:292-299(1996) [PubMed] [Europe PMC] [Abstract]
  2. "A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad."Hum. Mol. Genet. 5:2005-2011(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The human autosomal gene DAZLA: testis specificity and a candidate for male infertility."Hum. Mol. Genet. 5:2013-2017(1996) [PubMed] [Europe PMC] [Abstract]
  4. "A putative human male infertility gene DAZLA: genomic structure and methylation status."Mol. Hum. Reprod. 3:705-708(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1."Genomics 65:266-273(2000) [PubMed] [Europe PMC] [Abstract]
  10. "A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans."Proc. Natl. Acad. Sci. U.S.A. 98:7414-7419(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins."Proc. Natl. Acad. Sci. U.S.A. 100:538-543(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Association of a single-nucleotide polymorphism of the deleted-in-azoospermia-like gene with susceptibility to spermatogenic failure."J. Clin. Endocrinol. Metab. 87:5258-5264(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Kinked beta-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL."Proc. Natl. Acad. Sci. U.S.A. 108:18266-18271(2011) [PubMed] [Europe PMC] [Abstract]