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Dual Specificity Phosphatase 3 (DUSP3)

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VHR; Vaccinia Virus Phosphatase VH1-Related; Dual specificity protein phosphatase VHR

Dual Specificity Phosphatase 3 (DUSP3)
CCC F973
HGNC 3069
MGI 1919599
PubMed 24245651
RGD 1560049
UniProt P51452
Wiki DUSP3
DUSP3 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF973Hu01 Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF973Hu01 Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; ICC; IHC-P; IHC-F; ELISA.
MAF973Hu22 Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB
LAF973Hu71 Biotin-Linked Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC.
MAF973Hu21 Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
MAF973Hu23 Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Phosphatase 3 (DUSP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Phosphatase 3 (DUSP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) ELISA Kit Customized Service Offer
  1. "Expression cloning of a human dual-specificity phosphatase."Proc. Natl. Acad. Sci. U.S.A. 89:12170-12174(1992) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway."J. Biol. Chem. 274:13271-13280(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of the dual specificity protein phosphatase VHR."Science 272:1328-1331(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase."Biochemistry 41:3009-3017(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells."J. Med. Chem. 52:6716-6723(2009) [PubMed] [Europe PMC] [Abstract]