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Dual Specificity Phosphatase 4 (DUSP4)

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HVH2; MKP-2; MKP2; TYP; VH1 homologous phosphatase 2; MAP kinase phosphatase 2; Dual specificity protein phosphatase hVH2

Dual Specificity Phosphatase 4 (DUSP4)
CCC F974
HGNC 3070
MGI 2442191
PubMed 23966295
RGD 620625
UniProt Q13115
Wiki DUSP4
DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Phosphatase 4 (DUSP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Phosphatase 4 (DUSP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Phosphatase 4 (DUSP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 4 (DUSP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 4 (DUSP4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Phosphatase 4 (DUSP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Phosphatase 4 (DUSP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Phosphatase 4 (DUSP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 4 (DUSP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 4 (DUSP4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Phosphatase 4 (DUSP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Phosphatase 4 (DUSP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Phosphatase 4 (DUSP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 4 (DUSP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 4 (DUSP4) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase."J. Biol. Chem. 270:7197-7203(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation."J. Biol. Chem. 271:6497-6501(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Post-translational regulation of mitogen-activated protein kinase phosphatase-2 (MKP-2) by ERK."Cell Cycle 9:4650-4655(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2."Cell. Signal. 22:357-365(2010) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly."Proteins 76:763-767(2009) [PubMed] [Europe PMC] [Abstract]