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Dual Specificity Phosphatase 10 (DUSP10)

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MKP5; Mitogen-activated protein kinase phosphatase 5

Dual Specificity Phosphatase 10 (DUSP10)
CCC F980
HGNC 3065
MGI 1927070
PubMed 22711061
RGD 1310844
UniProt Q9Y6W6
Wiki DUSP10
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine / threonine and phosphotyrosine residues. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Phosphatase 10 (DUSP10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Phosphatase 10 (DUSP10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Phosphatase 10 (DUSP10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 10 (DUSP10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 10 (DUSP10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Phosphatase 10 (DUSP10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Phosphatase 10 (DUSP10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Phosphatase 10 (DUSP10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 10 (DUSP10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 10 (DUSP10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Phosphatase 10 (DUSP10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Phosphatase 10 (DUSP10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Phosphatase 10 (DUSP10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 10 (DUSP10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 10 (DUSP10) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5."J. Biol. Chem. 274:19949-19956(1999) [PubMed] [Europe PMC] [Abstract]
  2. "MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases."Oncogene 18:6981-6988(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase."J. Mol. Biol. 360:946-955(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5."Protein Sci. 16:880-886(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A distinct interaction mode revealed by the crystal structure of the kinase p38alpha with the MAPK binding domain of the phosphatase MKP5."Sci. Signal. 4:RA88-RA88(2011) [PubMed] [Europe PMC] [Abstract]