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Reticulon 4 (RTN4)

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NSP; ASY; NOGO; NSP-CL; RTN-X; Reticulon-5; Foocen; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog

Reticulon 4 (RTN4)
CCC F994
HGNC 14085
MGI 1915835
PubMed 16965550
RGD 620989
UniProt Q9NQC3
Wiki RTN4
Reticulon-4 is a protein belongs to the family of reticulon-encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.
Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF994Hu01 Recombinant Reticulon 4 (RTN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF994Hu01 Polyclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IP.
MAF994Hu21 Monoclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IP.
Assay Kits SEF994Hu ELISA Kit for Reticulon 4 (RTN4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Reticulon 4 (RTN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Reticulon 4 (RTN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Reticulon 4 (RTN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Reticulon 4 (RTN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Reticulon 4 (RTN4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Reticulon 4 (RTN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Reticulon 4 (RTN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Reticulon 4 (RTN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Reticulon 4 (RTN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Reticulon 4 (RTN4) ELISA Kit Customized Service Offer
  1. "Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping."Cytogenet. Cell Genet. 88:101-102(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Inhibitor of neurite outgrowth in humans."Nature 403:383-384(2000) [PubMed] [Europe PMC] [Abstract]
  3. "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity."Oncogene 19:5736-5746(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of a novel reticulon-like gene in human testis."Reproduction 123:227-234(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4."J. Mol. Biol. 325:299-323(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]