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Fibroblast Growth Factor Binding Protein 1 (FGFBP1)

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FGFBP; HBP17; 17 kDa heparin-binding growth factor-binding protein

Fibroblast Growth Factor Binding Protein 1 (FGFBP1)
CCC F996
HGNC 19695
MGI 1096350
PubMed 21436287
RGD 621211
UniProt Q14512
Wiki FGFBP1
FGFBP1 binds to both acidic (FGF1) and basic (FGF2;) fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2).HBP17 interacts with both FGF1 and FGF2. Like heparin, HBP17 protected both FGF molecules from acid inactivation. HBP17 inhibited the mitogenic activity of FGF1 more efficiently than that of FGF2 in the absence of heparin, and it blocked binding to a liver cell line.
The predicted 234-amino acid secreted protein contains a signal sequence and a potential N-linked glycosylation site. Expression was not detected in any other cell lines tested, including nontumorigenic epidermoid cell lines. Immunoblot analysis detected a 17-kD protein that comigrated with FGF2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibroblast Growth Factor Binding Protein 1 (FGFBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibroblast Growth Factor Binding Protein 1 (FGFBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibroblast Growth Factor Binding Protein 1 (FGFBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor Binding Protein 1 (FGFBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor Binding Protein 1 (FGFBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibroblast Growth Factor Binding Protein 1 (FGFBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibroblast Growth Factor Binding Protein 1 (FGFBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibroblast Growth Factor Binding Protein 1 (FGFBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor Binding Protein 1 (FGFBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor Binding Protein 1 (FGFBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibroblast Growth Factor Binding Protein 1 (FGFBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibroblast Growth Factor Binding Protein 1 (FGFBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibroblast Growth Factor Binding Protein 1 (FGFBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor Binding Protein 1 (FGFBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor Binding Protein 1 (FGFBP1) ELISA Kit Customized Service Offer
  1. "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors."J. Biol. Chem. 266:16778-16785(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer."Nat. Med. 3:1137-1140(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core."J. Biol. Chem. 276:10263-10271(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein."J. Biol. Chem. 276:40247-40253(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display."J. Biol. Chem. 281:1137-1144(2006) [PubMed] [Europe PMC] [Abstract]