Gamma-Aminobutyric Acid A Receptor Beta 1 (gABRb1)

Gamma-aminobutyric acid (GABA) receptors are a family of proteins involved in the GABAergic neurotransmission of the mammalian central nervous system. GABRB1 is a member of the GABA-A receptor gene family of heteromeric pentameric ligand-gated ion channels through which GABA, the major inhibitory neurotransmitter in the mammalian brain, acts. GABA-A receptors are the site of action of a number of important pharmacologic agents including barbiturates, benzodiazepines, and ethanol. GABRB1, like GABRA2, has been shown by in situ hybridization to be located on 4p13-p12. The murine homologs of GABRA2 and GABRB1 are tightly linked on mouse chromosome 5 between the markers Pgm-1 and Kit. The 2 genes map near the mouse 'circling mutation' pi (pirouette).