Histamine Receptor H2 (HRH2)

receptors are positively coupled to adenylate cyclase via G_s. It is a potent stimulant of cAMP production. It increases the intracellular Ca²⁺ concentrations and release Ca²⁺ from intracellular stores. The drug betazole is an example of a Histamine H₂ receptor agonist.Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H₁, H₂, H₃ and H₄. The histamine receptor H₂ belongs to the rhodopsin-like family of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation.