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Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5)

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FEX; GPR49; GPR67; HG38; G Protein-Coupled Receptor 49

Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5)
CCC G047
HGNC 4504
MGI 1341817
PubMed 9642114
RGD 1307733
UniProt O75473
Wiki LGR5
The receptors for glycoprotein hormones such as follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH) are G protein-coupled, 7-transmembrane receptors (GPCRs) with large N-terminal extracellular domains. Leucine-rich repeat (LRR)-containing GPCRs (LGRs) form a subgroup of the GPCR superfamily. The deduced 907-amino acid 7-transmembrane GPR49 protein has an N-terminal signal peptide, 16 LRRs, and is approximately 35% identical to FSH receptor, TSH receptor, and luteinizing hormone (LH) receptor. Functional analysis, however, did not show activation of GPR49 by any ligands of those receptors. Northern blot analysis revealed expression of a 5.0-kb GPR49 transcript in skeletal muscle, spinal cord, and various subregions of brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG047Hu01 Recombinant Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG047Hu01 Polyclonal Antibody to Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) WB; IHC; ICC; IP.
Assay Kits SEG047Hu ELISA Kit for Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG047Mu01 Recombinant Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Polyclonal Antibody Customized Service Offer
Assay Kits SEG047Mu ELISA Kit for Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) ELISA Kit Customized Service Offer
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  12. "Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network."J. Biol. Chem. 288:10286-10297(2013) [PubMed] [Europe PMC] [Abstract]
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