G Protein Coupled Receptor 22 (GPR22)

O'Dowd et al. (1997) reported the discovery of 4 novel human putative G protein-coupled receptor (GPR) genes. By screening an EST database, they identified cDNA sequences that partially encode 3 additional GPRs. These cDNA fragments were used to screen a genomic library to isolate the full-length coding region of the genes. This resulted in the isolation of genes GPR21, GPR22, and GPR23. The 4 encoded receptors share significant identity to each other and to other members of the receptor family.

O'Dowd et al. (1997) mapped the GPR22 gene to 7q22-q31.1 by fluorescence in situ hybridization. Northern blot analysis revealed expression of GPR22 and GPR20 in several human brain regions.