Purinergic Receptor P2X, Ligand Gated Ion Channel 4 (P2RX4)

P2X purinoceptor 4 is a protein belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.

P2X4 expression was nearly undetectable in promyelocytes and after granulocyte differentiation. During monocytic differentiation, P2X4 was highly expressed, showing a biphasic peak in early and later stages of differentiation.