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Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12)

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ADPG-R; HORK3; P2T(AC); P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; SP1999; ADP-glucose receptor; P2Y12 platelet ADP receptor

Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12)
CCC G086
HGNC 18124
MGI 1918089
PubMed 22996695
RGD 621681
UniProt Q9H244
Wiki P2Y12
In the field of molecular biology, the P2Y12 protein is found on the surface of blood platelet cells and is an important regulator in blood clotting.
P2RY12belongs to a group of G protein-coupled purinergic receptors and is a chemoreceptor for adenosine diphosphate (ADP). The P2Y family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG086Hu01 Recombinant Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG086Hu21 Monoclonal Antibody to Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) WB; IHC; ICC; IP.
PAG086Hu01 Polyclonal Antibody to Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) WB; IHC; ICC; IP.
Assay Kits SEG086Hu ELISA Kit for Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) ELISA Kit Customized Service Offer
  1. "Identification of the platelet ADP receptor targeted by antithrombotic drugs."Nature 409:202-207(2001) [PubMed] [Europe PMC] [Abstract]
  2. "ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999."J. Biol. Chem. 276:8608-8615(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y1 receptor."Mol. Pharmacol. 60:432-439(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of G protein-coupled receptor genes from the human genome sequence."FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Structure of the human P2Y12 receptor in complex with an antithrombotic drug." Nature 509:115-118(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Agonist-bound structure of the human P2Y12 receptor."Nature 509:119-122(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding."Proc. Natl. Acad. Sci. U.S.A. 100:1978-1983(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a new dysfunctional platelet P2Y12 receptor variant associated with bleeding diathesis."Blood 125:1006-1013(2015) [PubMed] [Europe PMC] [Abstract]