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Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4)

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NRU; P2P; P2Y4; UNR; P2Y Purinoceptor 4; Uridine nucleotide receptor

Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4)
CCC G087
HGNC 8542
MGI 1926594
PubMed 8537336
RGD 61798
UniProt P51582
Wiki P2RY4
P2Y purinoceptor 4 is a protein belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.
The encoded protein, UNR, has greatest overall identity (54%) with human P2U purinoceptor (P2RY2). The greatest degree of amino acid identity occurs within the putative 7-transmembrane domain, where it demonstrates 74% identity. Dendrogram analysis of the G protein-coupled P2 purinoceptors and UNR indicated that these receptors belong to a family that may be more aptly named nucleotide receptors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4) ELISA Kit Customized Service Offer
  1. "Cloning and functional expression of a human uridine nucleotide receptor."J. Biol. Chem. 270:30849-30852(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene."J. Biol. Chem. 270:30845-30848(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor."FEBS Lett. 384:260-264(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. Ser-333 and Ser-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor."J. Biol. Chem. 276:11939-11948(2001) [PubMed] [Europe PMC] [Abstract]