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Melanin Concentrating Hormone Receptor 2 (MCHR2)

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MCH2; GPR145; MCH2R; SLT; GPRv17; G Protein-Coupled Receptor 145

Melanin Concentrating Hormone Receptor 2 (MCHR2)
CCC G090
HGNC 20867
PubMed 20937223
UniProt Q969V1
Wiki MCHR2
Melanin-concentrating hormone receptor 2 is found in humans, dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH2 gene and its receptor product.
Melanin Concentrating Hormone Receptor 2 is receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Melanin Concentrating Hormone Receptor 2 (MCHR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Melanin Concentrating Hormone Receptor 2 (MCHR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melanin Concentrating Hormone Receptor 2 (MCHR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Melanin Concentrating Hormone Receptor 2 (MCHR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Melanin Concentrating Hormone Receptor 2 (MCHR2) ELISA Kit Customized Service Offer
  1. "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor."Biochem. Biophys. Res. Commun. 283:1013-1018(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R." Proc. Natl. Acad. Sci. U.S.A. 98:7564-7569(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, MCH-R2."J. Biol. Chem. 276:34664-34670(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor."J. Biol. Chem. 276:20125-20129(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2."Obes. Res. 12:1327-1334(2004) [PubMed] [Europe PMC] [Abstract]