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Clathrin, Heavy Polypeptide (CLTC)

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CLTCL2; Hc; CLH17; Clathrin,Heavy Polypeptide-Like 2; Clathrin heavy chain 1; Clathrin heavy chain on chromosome 17

Clathrin, Heavy Polypeptide (CLTC)
CCC G092
HGNC 2092
MGI 2388633
RGD 2364
UniProt Q00610
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. Clathrin molecules have a triskelion structure composed of 3 noncovalently bound heavy chains (CLTC) and 3 light chains.
CHC overexpression enhanced p53-dependent transactivation, whereas reduction of CHC expression by RNA interference attenuated p53 transcriptional activity. CHC bound to a p53-responsive promoter in vivo and stabilized the interaction between p53 and p300 (EP300) to promote p53-mediated transcription.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG092Hu01 Recombinant Clathrin, Heavy Polypeptide (CLTC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Clathrin, Heavy Polypeptide (CLTC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Clathrin, Heavy Polypeptide (CLTC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Clathrin, Heavy Polypeptide (CLTC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Clathrin, Heavy Polypeptide (CLTC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Clathrin, Heavy Polypeptide (CLTC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Clathrin, Heavy Polypeptide (CLTC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Clathrin, Heavy Polypeptide (CLTC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Clathrin, Heavy Polypeptide (CLTC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Clathrin, Heavy Polypeptide (CLTC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Clathrin, Heavy Polypeptide (CLTC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Clathrin, Heavy Polypeptide (CLTC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Clathrin, Heavy Polypeptide (CLTC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Clathrin, Heavy Polypeptide (CLTC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Clathrin, Heavy Polypeptide (CLTC) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter."Genomics 11:174-178(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]