≡

Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM)

[Edit]

LAP; CALM; CLTH; Clathrin assembly lymphoid myeloid leukemia protein

Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM)
CCC G095
HGNC 15514
MGI 2385902
PubMed 20838239
RGD 621054
UniProt Q13492
Wiki PICALM
Dreyling et al. (1996) identified a breakpoint on chromosome 11 involving the previously unknown gene, CALM. CALM has a very high homology to the murine clathrin assembly protein ap3. Mao et al. (2001) determined the crystal structure of the N-terminal domain (the NAP domain) of the Drosophila Lap protein, which is homologous to human PICALM. The structure revealed a novel fold consisting of a large double layer of sheets of 10 alpha helices and a unique site for binding phosphoinositides.This motif is found in other proteins predicted to have domains of similar structure (e.g., Huntingtin-interacting protein-1). The structure is in part similar to the epsin N-terminal (ENTH) domain, but epsin lacks the phosphatidylinositol-4,5-bisphosphate-binding site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG095Hu01 Recombinant Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG095Hu21 Monoclonal Antibody to Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) WB; IHC; ICC; IP.
PAG095Hu01 Polyclonal Antibody to Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) WB; IHC; ICC; IP.
Assay Kits SEG095Hu ELISA Kit for Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) ELISA Kit Customized Service Offer
  1. "The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family."Proc. Natl. Acad. Sci. U.S.A. 93:4804-4809(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides."Leukemia 12:1404-1410(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic."Mol. Biol. Cell 10:2687-2702(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10."Oncogene 25:4099-4109(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]