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Adaptor Related Protein Complex 2 Alpha 1 (AP2a1)

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ADTAA; CLAPA1; Adaptin Alpha; 100 kDa coated vesicle protein A; Clathrin assembly protein complex 2 alpha-A large chain; Plasma membrane adaptor HA2/AP2 adaptin alpha A

Adaptor Related Protein Complex 2 Alpha 1 (AP2a1)
CCC G104
HGNC 561
MGI 101921
PubMed 2564002
RGD 1306254
UniProt O95782
Wiki AP2A1
AP2a1 encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles.
Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.The alpha adaptins are exclusively found in the endocytic coated vesicles. The 2 mouse proteins are 84% identical.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG104Hu01 Recombinant Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 2 Alpha 1 (AP2a1) ELISA Kit Customized Service Offer
  1. "Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene."Gene 289:191-199(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis."Hum. Mol. Genet. 10:1807-1817(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors."J. Biol. Chem. 277:49158-49166(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network."Cell Struct. Funct. 28:419-429(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Adaptors for clathrin coats: structure and function."Annu. Rev. Cell Dev. Biol. 20:153-191(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway."J. Cell Sci. 121:4008-4017(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]