Adaptor Related Protein Complex 2 Sigma 1 (AP2s1)

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain.

AP17 is the 17-kD component of the AP2 clathrin-associated protein complex. Winterpacht et al. (1996) cloned the AP17 gene, CLAPS2, from a human kidney cDNA library using the rat gene as a probe. The cDNA encodes a predicted 142-amino acid protein that is 98% homologous to that of rat. Holzmann et al. (1998) identified additional CLAPS2 cDNAs and found that the predicted human and rat proteins are identical. They also isolated cDNAs corresponding to an alternatively spliced CLAPS2 transcript encoding AP17-delta, a protein variant lacking 38 amino acids of AP17.