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Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1)

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Epsilon-adaptin; AP-4 adaptor complex subunit epsilon

Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1)
CCC G117
HGNC 573
MGI 1336993
PubMed 23472171
RGD 1562199
UniProt Q9UPM8
Wiki AP4E1
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways.
AP4E1 shows an apparent molecular mass of about 140 kD and is part of a 280-kD complex containing AP4B1, AP4S1, and AP4M1. By immunoprecipitation and reprecipitation of HeLa cell lysates, they confirmed interaction between AP4B1 and AP4E1. Immunolocalization of the AP4B1 subunit in HeLa cells revealed that the AP4 complex associates with the trans-Golgi network or an adjacent structure. The association was sensitive to brefeldin-A treatment, indicating that the membrane localization of AP4 is dependent upon the small GTP-binding protein ARF1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 4 Epsilon 1 (AP4e1) ELISA Kit Customized Service Offer
  1. "Characterization of a fourth adaptor-related protein complex."Mol. Biol. Cell 10:2787-2802(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system."Biochem. Biophys. Res. Commun. 284:1083-1089(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Adaptor protein complex-4 (AP-4) deficiency causes a novel autosomal recessive cerebral palsy syndrome with microcephaly and intellectual disability."J. Med. Genet. 48:141-144(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]