≡

Adaptor Related Protein Complex 4 Sigma 1 (AP4s1)

[Edit]

CLA20; AP47B; Sigma-4-adaptin

Adaptor Related Protein Complex 4 Sigma 1 (AP4s1)
CCC G119
HGNC 575
MGI 1337065
PubMed 21620353
UniProt Q9Y587
Wiki AP4S1
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. The predicted 144-amino acid Ap4s1 protein has a calculated molecular mass of 16.8 kD. Northern blot analysis revealed a 1.2- to 1.4-kb transcript in all mouse tissues examined.
AP4S1 shows an apparent molecular mass of about 17 kD and is part of a 280-kD complex containing AP4B1, AP4E1, and AP4M1. Immunolocalization of the AP4B1 subunit in HeLa cells indicated that the AP4 complex associates with the trans-Golgi network or an adjacent structure. The association was sensitive to brefeldin-A treatment, indicating that the membrane localization of AP4 is dependent upon the small GTP-binding protein ARF1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG119Hu01 Recombinant Adaptor Related Protein Complex 4 Sigma 1 (AP4s1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 4 Sigma 1 (AP4s1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 4 Sigma 1 (AP4s1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 4 Sigma 1 (AP4s1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 4 Sigma 1 (AP4s1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 4 Sigma 1 (AP4s1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 4 Sigma 1 (AP4s1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 4 Sigma 1 (AP4s1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 4 Sigma 1 (AP4s1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 4 Sigma 1 (AP4s1) ELISA Kit Customized Service Offer
  1. "Characterization of a fourth adaptor-related protein complex."Mol. Biol. Cell 10:2787-2802(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature."Am. J. Hum. Genet. 88:788-795(2011) [PubMed] [Europe PMC] [Abstract]