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Amyloid Beta Precursor Like Protein 2 (APLP2)

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APPH; APPL2; CDEBP; Amyloid protein homolog; CDEI box-binding protein

Amyloid Beta Precursor Like Protein 2 (APLP2)
CCC G122
HGNC 598
MGI 88047
PubMed 8220435
RGD 2128
UniProt Q06481
Wiki APLP2
APLP2 associates with antigen presentation molecules like MHC class I molecules and regulates their surface expression by enhancing endocytosis.May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.In placenta, brain, heart, lung, liver, kidney and endothelial tissues.
APLP1 and APLP2 double knockout mice display hypoglycemia and hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG122Hu01 Recombinant Amyloid Beta Precursor Like Protein 2 (APLP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG122Hu01 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IP.
MAG122Hu21 Monoclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IP.
Assay Kits SEG122Hu ELISA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amyloid Beta Precursor Like Protein 2 (APLP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amyloid Beta Precursor Like Protein 2 (APLP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family."Biochemistry 32:4481-4486(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor."Nat. Genet. 5:95-99(1993) [PubMed] [Europe PMC] [Abstract]
  3. "A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein."DNA Cell Biol. 13:1137-1143(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "USF binds to the APB alpha sequence in the promoter of the amyloid beta-protein precursor gene."Nucleic Acids Res. 23:2734-2741(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Expression and characterization of the human YWK-II gene, encoding a sperm membrane protein related to the alzheimer betaA4-amyloid precursor protein."Mol. Hum. Reprod. 6:1069-1078(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Expression, purification and characterization of a Kunitz-type protease inhibitor domain from human amyloid precursor protein homolog."FEBS Lett. 338:53-57(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]