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Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2)

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IleRS; Isoleucyl-tRNA synthetase

Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2)
CCC G131
HGNC 29685
MGI 1919586
PubMed 21878944
RGD 1311857
UniProt Q9NSE4
By searching databases for aminoacyl-tRNA synthetases containing a mitochondrial targeting sequence, Bonnefond et al. (2005) identified IARS2, which the called mitochondrial ILERS. The deduced 993-amino acid protein has an N-terminal mitochondrial targeting signal with a predicted cleavage site after residue 61. IARS2 has characteristics of a class I mitochondrial aminoacyl-tRNA synthetase, including a classical Rossmann fold.
Bonnefond et al. (2005) determined that the IARS2 gene contains 23 exons and spans 53.4 kb.By genomic sequence analysis,
Bonnefond et al. (2005) mapped the IARS2 gene to chromosome 1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG131Hu01 Recombinant Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG131Mu01 Recombinant Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG131Ra01 Recombinant Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Isoleucyl tRNA Synthetase 2, Mitochondrial (IARS2) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Mutation in the nuclear-encoded mitochondrial isoleucyl-tRNA synthetase IARS2 in patients with cataracts, growth hormone deficiency with short stature, partial sensorineural deafness, and peripheral neuropathy or with Leigh syndrome."Hum. Mutat. 35:1285-1289(2014) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]