Cysteinyl tRNA Synthetase 2, Mitochondrial (CARS2)

By searching databases for aminoacyl-tRNA synthetases containing a mitochondrial targeting sequence, Bonnefond et al. (2005) identified CARS2, which the called mitochondrial CYSRS.

The deduced 564-amino acid protein has an N-terminal mitochondrial targeting signal with a predicted cleavage site after residue 62. CARS2 has characteristics of a class I mitochondrial aminoacyl-tRNA synthetase, including a classical Rossmann fold.

Bonnefond et al. (2005) determined that the CARS2 gene contains 15 exons and spans 64.7 kb. By genomic sequence analysis, Bonnefond et al. (2005) mapped the CARS2 gene to chromosome 13.