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X-Ray Repair Cross Complementing 4 (XRCC4)

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DNA repair protein XRCC4

X-Ray Repair Cross Complementing 4 (XRCC4)
CCC G145
HGNC 12831
MGI 1333799
PubMed 19332554
RGD 1359573
UniProt Q13426
Wiki XRCC4
X-Ray Repair Cross-Complementing 4 functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors.
This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. This gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant X-Ray Repair Cross Complementing 4 (XRCC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to X-Ray Repair Cross Complementing 4 (XRCC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to X-Ray Repair Cross Complementing 4 (XRCC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for X-Ray Repair Cross Complementing 4 (XRCC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for X-Ray Repair Cross Complementing 4 (XRCC4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant X-Ray Repair Cross Complementing 4 (XRCC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to X-Ray Repair Cross Complementing 4 (XRCC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to X-Ray Repair Cross Complementing 4 (XRCC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for X-Ray Repair Cross Complementing 4 (XRCC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for X-Ray Repair Cross Complementing 4 (XRCC4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant X-Ray Repair Cross Complementing 4 (XRCC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to X-Ray Repair Cross Complementing 4 (XRCC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to X-Ray Repair Cross Complementing 4 (XRCC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for X-Ray Repair Cross Complementing 4 (XRCC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for X-Ray Repair Cross Complementing 4 (XRCC4) ELISA Kit Customized Service Offer
  1. "The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination."Cell 83:1079-1089(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV."Curr. Biol. 7:588-598(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase."J. Biol. Chem. 273:1794-1801(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system."DNA Repair 3:267-276(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells."Nature 388:492-495(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase."J. Biol. Chem. 275:26196-26205(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Ku recruits the XRCC4-ligase IV complex to DNA ends."Mol. Cell. Biol. 20:2996-3003(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Defining interactions between DNA-PK and ligase IV/XRCC4."DNA Repair 1:225-235(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment."J. Mol. Biol. 326:93-103(2003) [PubMed] [Europe PMC] [Abstract]
  12. "The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4."DNA Repair 3:1493-1502(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Monoubiquitination of the nonhomologous end joining protein XRCC4."Biochem. Biophys. Res. Commun. 341:175-183(2006) [PubMed] [Europe PMC] [Abstract]
  14. "XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining."Cell 124:301-313(2006) [PubMed] [Europe PMC] [Abstract]
  15. "SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair."Mol. Cell. Biol. 26:1786-1794(2006) [PubMed] [Europe PMC] [Abstract]
  16. "A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses."EMBO J. 26:2094-2103(2007) [PubMed] [Europe PMC] [Abstract]
  17. "APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks."Mol. Cell. Biol. 27:3793-3803(2007) [PubMed] [Europe PMC] [Abstract]
  18. "APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation."DNA Repair 7:292-302(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "Crystal structure of an Xrcc4-DNA ligase IV complex."Nat. Struct. Biol. 8:1015-1019(2001) [PubMed] [Europe PMC] [Abstract]
  26. "Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive."J. Mol. Biol. 334:215-228(2003) [PubMed] [Europe PMC] [Abstract]