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X-Ray Repair Cross Complementing 3 (XRCC3)

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DNA repair protein XRCC3

X-Ray Repair Cross Complementing 3 (XRCC3)
CCC G146
HGNC 12830
MGI 1921585
PubMed 23438602
UniProt O43542
Wiki XRCC3
XRCC3 encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. These results indicated that XRCC3 function is not limited to HR initiation, but extends to later stages in formation and resolution of HR intermediates, possibly by stabilizing heteroduplex DNA. The results further demonstrated that HR defects can promote genomic instability not only through failure to initiate HR, but also through aberrant processing of HR intermediates. The authors suggested that both mechanisms may contribute to carcinogenesis in HR-deficient cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG146Hu01 Recombinant X-Ray Repair Cross Complementing 3 (XRCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for X-Ray Repair Cross Complementing 3 (XRCC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for X-Ray Repair Cross Complementing 3 (XRCC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG146Mu01 Recombinant X-Ray Repair Cross Complementing 3 (XRCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for X-Ray Repair Cross Complementing 3 (XRCC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for X-Ray Repair Cross Complementing 3 (XRCC3) ELISA Kit Customized Service Offer
  1. "XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages."Mol. Cell 1:783-793(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and purification of two distinct complexes containing the five RAD51 paralogs."Genes Dev. 15:3296-3307(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Variants in DNA double-strand break repair genes and breast cancer susceptibility."Hum. Mol. Genet. 11:1399-1407(2002) [PubMed] [Europe PMC] [Abstract]
  5. "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51."J. Biol. Chem. 277:8406-8411(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells."Nucleic Acids Res. 30:1009-1015(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Domain mapping of the Rad51 paralog protein complexes."Nucleic Acids Res. 32:169-178(2004) [PubMed] [Europe PMC] [Abstract]
  8. "RAD51C is required for Holliday junction processing in mammalian cells."Science 303:243-246(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51."J. Cell. Biochem. 96:1095-1109(2005) [PubMed] [Europe PMC] [Abstract]
  10. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome."J. Biol. Chem. 285:18984-18990(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair."J. Biol. Chem. 286:41758-41766(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy."J. Cell Sci. 126:348-359(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway."Mol. Cell. Biol. 33:387-395(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair."Oncogene 33:4803-4812(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy."J. Biol. Chem. 285:13349-13356(2010) [PubMed] [Europe PMC] [Abstract]
  19. "A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer."Cancer Res. 60:5612-5616(2000) [PubMed] [Europe PMC] [Abstract]