Ubiquitin Like Modifier Activating Enzyme 5 (UBA5)

UBA5 encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A pseudogene located on chromosome 1 has also been identified.

The deduced protein has a predicted molecular mass of 43.9 kD and contains a conserved ThiF domain with a nearby cysteine residue similar to ubiquitin activating enzyme E1C (UBE1C). highest UBE1DC1 expression in spleen, high expression in most other tissues examined, and low expression in colon, prostate, brain, and ovary.