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Ubiquitin Like Modifier Activating Enzyme 6 (UBA6)

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UBE1L2; MOP-4; Monocyte protein 4; Ubiquitin-Activating Enzyme E1-Like 2; Ubiquitin-activating enzyme E1-like protein 2

Ubiquitin Like Modifier Activating Enzyme 6 (UBA6)
CCC G156
HGNC 25581
MGI 1913894
PubMed 18353650
RGD 1308324
UniProt A0AVT1
Modification of proteins with ubiquitin (UBB) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins.
The deduced 1,052-amino acid protein contains an N-terminal adenylation domain with 2 ThiF-homology regions, a catalytic cysteine domain, and a C-terminal ubiquitin-fold domain that functions to recruit E2s. UBE1L2 shares approximately 40% overall sequence identity with UBE1. Database analysis revealed wide expression of UBE1L2 in human tissues and cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG156Hu01 Recombinant Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG156Mu01 Recombinant Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Modifier Activating Enzyme 6 (UBA6) ELISA Kit Customized Service Offer
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  2. "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging."Nature 447:1135-1138(2007) [PubMed] [Europe PMC] [Abstract]
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  7. "E1-L2 activates both ubiquitin and FAT10."Mol. Cell 27:1014-1023(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
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  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]