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Ubiquitin Like Modifier Activating Enzyme 1 (UBA1)

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UBE1X; POC20; A1S9T; UBA1A; A1S9; UBE1; A1ST; SMAX2; AMCX1; GXP1; Ubiquitin-activating enzyme E1

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1)
CCC G157
HGNC 12469
MGI 98890
PubMed 23873149
RGD 1359327
UniProt P22314
Wiki UBA1
UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. The cDNA recognized a single 3.5-kb E1 message that was ubiquitous among tissues and cell lines studied. In vitro translation of the mRNA yielded a major product of approximately 110 kD, which was immunoprecipitated by the antihuman E1 antibody used to identify the clone.Database analysis detected variable UBE1 expression in all human tissues and cell lines examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) ELISA Kit Customized Service Offer
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  7. , Submitted (MAR-2007) to UniProtKB
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  14. "Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival."Nature 438:224-228(2005) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage."Cell Cycle 11:1573-1582(2012) [PubMed] [Europe PMC] [Abstract]
  23. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy."Am. J. Hum. Genet. 82:188-193(2008) [PubMed] [Europe PMC] [Abstract]
  26. "Clinical and neuropathological features of X-linked spinal muscular atrophy (SMAX2) associated with a novel mutation in the UBA1 gene."Neuromuscul. Disord. 23:391-398(2013) [PubMed] [Europe PMC] [Abstract]