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Ubiquitin Like Modifier Activating Enzyme 3 (UBA3)

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UBE1C; NEDD8-Activating Enzyme E1 Catalytic Subunit; Ubiquitin-like modifier-activating enzyme 3; Ubiquitin-activating enzyme E1C

Ubiquitin Like Modifier Activating Enzyme 3 (UBA3)
CCC G159
HGNC 12470
MGI 1341217
PubMed 16275315
RGD 621084
UniProt Q8TBC4
Wiki UBE1C
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.
UBA3 encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG159Hu01 Recombinant Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Modifier Activating Enzyme 3 (UBA3) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway."J. Biol. Chem. 274:12036-12042(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A new NEDD8-ligating system for cullin-4A."Genes Dev. 12:2263-2268(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer."J. Biol. Chem. 278:26823-26830(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1."Mol. Cell 12:1427-1437(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8."Nature 422:330-334(2003) [PubMed] [Europe PMC] [Abstract]
  12. "A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8."Nat. Struct. Mol. Biol. 11:927-935(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1."Mol. Cell 17:341-350(2005) [PubMed] [Europe PMC] [Abstract]
  14. "E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification."Mol. Cell 33:483-495(2009) [PubMed] [Europe PMC] [Abstract]