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Heat Shock 40kDa Protein 4 (HSPF4)

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DNAJA1; DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSP-F4; hDJ-2; NEDD7; DnaJ(Hsp40)Homolog,Subfamily A,Member 1; DnaJ protein homolog 2

Heat Shock 40kDa Protein 4 (HSPF4)
CCC G167
HGNC 5229
MGI 1270129
RGD 620942
UniProt P31689
DNAJA1 is most identical to YDJ1, which may be involved in the transport of certain proteins into the mitochondria and endoplasmic reticulum.Transplantation experiments with fluorescence-tagged spermatogonia into Dja1- mice revealed a primary defect of Sertoli cells in maintaining spermiogenesis at steps 8 and 9.
In Sertoli cells of Dja1- mice, the androgen receptor markedly accumulated with enhanced transcription of several androgen-responsive genes, including Pem (MUC1) and testis-derived transcript (TES). Disruption of Sertoli-germ cell adherens junctions was also evident in Dja1- mice. Experiments with Dja1- fibroblasts and primary Sertoli cells indicated aberrant androgen receptor signaling.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG167Hu01 Recombinant Heat Shock 40kDa Protein 4 (HSPF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG167Hu01 Polyclonal Antibody to Heat Shock 40kDa Protein 4 (HSPF4) WB; IHC; ICC; IP.
Assay Kits SEG167Hu ELISA Kit for Heat Shock 40kDa Protein 4 (HSPF4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heat Shock 40kDa Protein 4 (HSPF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heat Shock 40kDa Protein 4 (HSPF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heat Shock 40kDa Protein 4 (HSPF4) Polyclonal Antibody Customized Service Offer
Assay Kits SEG167Mu ELISA Kit for Heat Shock 40kDa Protein 4 (HSPF4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heat Shock 40kDa Protein 4 (HSPF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heat Shock 40kDa Protein 4 (HSPF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heat Shock 40kDa Protein 4 (HSPF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heat Shock 40kDa Protein 4 (HSPF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heat Shock 40kDa Protein 4 (HSPF4) ELISA Kit Customized Service Offer
  1. "Human cDNA encoding DnaJ protein homologue."Biochim. Biophys. Acta 1174:114-116(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein."Biochim. Biophys. Acta 1174:111-113(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Expression of a novel DnaJA1 alternative splicing in human testis and sperm."Int. J. Androl. 27:343-349(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria."J. Biochem. 121:890-895(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70."J. Biol. Chem. 275:24728-24734(2000) [PubMed] [Europe PMC] [Abstract]
  8. "hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria."Cell Death Differ. 11:390-402(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro."J. Biol. Chem. 289:1402-1414(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer."Biochemistry 53:1360-1372(2014) [PubMed] [Europe PMC] [Abstract]