-96172.jpg)
Advillin is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus.
A new member of the gelsolin/villin family of actin regulatory proteins was initially identified by screening an adult murine brain cDNA library with a probe for bovine adseverin. The predicted amino acid sequence of the 92 kDa murine protein p92 (advillin) is 75% homologous to villin and 65% homologous to gelsolin and adseverin. It shares a six domain structure with other gelsolin family members and has a carboxy-terminal headpiece, similar to, yet distinct from, villin.
A new member of the gelsolin/villin family of actin regulatory proteins was initially identified by screening an adult murine brain cDNA library with a probe for bovine adseverin. The predicted amino acid sequence of the 92 kDa murine protein p92 (advillin) is 75% homologous to villin and 65% homologous to gelsolin and adseverin. It shares a six domain structure with other gelsolin family members and has a carboxy-terminal headpiece, similar to, yet distinct from, villin.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Advillin (AVIL) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Advillin (AVIL) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Advillin (AVIL) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEG172Hu | ELISA Kit for Advillin (AVIL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG172Mu01 | Recombinant Advillin (AVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAG172Mu01 | Polyclonal Antibody to Advillin (AVIL) | WB; IHC; ICC; IP. |
| Assay Kits | SEG172Mu | ELISA Kit for Advillin (AVIL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG172Ra01 | Recombinant Advillin (AVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAG172Ra01 | Polyclonal Antibody to Advillin (AVIL) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Advillin (AVIL) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Advillin (AVIL) | ELISA Kit Customized Service Offer |
- "Advillin (p92): a new member of the gelsolin/villin family of actin regulatory proteins."J. Cell Sci. 111:2129-2136(1998) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13-14 (IBD2)."Gene 288:179-185(2002) [PubMed] [Europe PMC] [Abstract]
- "Functional genomic screen for modulators of ciliogenesis and cilium length."Nature 464:1048-1051(2010) [PubMed] [Europe PMC] [Abstract]
- "Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements."Protein Sci. 13:1276-1287(2004) [PubMed] [Europe PMC] [Abstract]