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Dedicator Of Cytokinesis 8 (DOCK8)

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ZIR8

Dedicator Of Cytokinesis 8 (DOCK8)
CCC G178
HGNC 19191
MGI 1921396
PubMed 22006977
RGD 1561588
UniProt Q8NF50
Wiki Dock8
Dock8 was identified during a yeast two hybrid (YTH) screen for proteins that interact with the Rho family small G protein Cdc42.Subsequent northern blot analysis revealed high levels of Dock8 expression in the placenta, lung, kidney and pancreas as well as lower levels in the heart, brain and skeletal muscle.
Dock8 shares the same core domain arrangement as all other DOCK proteins, with a DHR2 domain which, in other proteins, contains GEF activity and a DHR1 domain known, in other proteins, to interact with phospholipids. In the YTH system Dock8 was reported to interact with both Rac1 and Cdc42. However, no stable interaction between Dock8 and these small G proteins was observed in a GST-pulldown assay.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dedicator Of Cytokinesis 8 (DOCK8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 8 (DOCK8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 8 (DOCK8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dedicator Of Cytokinesis 8 (DOCK8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 8 (DOCK8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 8 (DOCK8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dedicator Of Cytokinesis 8 (DOCK8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 8 (DOCK8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 8 (DOCK8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 8 (DOCK8) ELISA Kit Customized Service Offer
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  8. "Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities."Genomics 91:195-202(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Combined immunodeficiency associated with DOCK8 mutations."N. Engl. J. Med. 361:2046-2055(2009) [PubMed] [Europe PMC] [Abstract]
  13. "20 ans apres: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition." Eur. J. Hum. Genet. 22:776-783(2014) [PubMed] [Europe PMC] [Abstract]