Dedicator Of Cytokinesis 11 (DOCK11)
[Edit]ZIZ2; Zizimin 2; Activated Cdc42-associated guanine nucleotide exchange factor
Dock11 exhibits the same domain arrangement as other memebrs of the DOCK-D/Zizimin subfamily and shares the highest level of sequence identity with Dock9. It contains a DHR2 domain which mediates GEF activity and a DHR1 domain domain which may interact with membrane phospholipids. It also contains an N-terminal PH domain which may be involved in its recruitment to the plasma membrane. Dock11 binds and activates nucleotide-free Cdc42 via its DHR2 domain and has also been reported to mediate positive feedback on active, GTP-bound Cdc42, although this interaction required a small N-terminal region of Dock11 in addition to the DHR2 domain. Cdc42 in turn regulates signaling pathways that control diverse cellular functions including morphology, migration, endocytosis and cell cycle progression.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Dedicator Of Cytokinesis 11 (DOCK11) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Dedicator Of Cytokinesis 11 (DOCK11) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Dedicator Of Cytokinesis 11 (DOCK11) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Dedicator Of Cytokinesis 11 (DOCK11) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dedicator Of Cytokinesis 11 (DOCK11) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Dedicator Of Cytokinesis 11 (DOCK11) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Dedicator Of Cytokinesis 11 (DOCK11) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Dedicator Of Cytokinesis 11 (DOCK11) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Dedicator Of Cytokinesis 11 (DOCK11) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dedicator Of Cytokinesis 11 (DOCK11) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Dedicator Of Cytokinesis 11 (DOCK11) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Dedicator Of Cytokinesis 11 (DOCK11) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Dedicator Of Cytokinesis 11 (DOCK11) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Dedicator Of Cytokinesis 11 (DOCK11) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dedicator Of Cytokinesis 11 (DOCK11) | ELISA Kit Customized Service Offer |
- "Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42."J. Biol. Chem. 281:35253-35262(2006) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]