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Dedicator Of Cytokinesis 5 (DOCK5)

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Dedicator Of Cytokinesis 5 (DOCK5)
CCC G185
HGNC 23476
MGI 2652871
PubMed 18600791
RGD 1306872
UniProt Q9H7D0
Wiki Dock5
Dock5 is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. Dock5 shares significant sequence identity with Dock180, the archetypal member of the DOCK family. It is therefore predicted to partake in similar interactions although this has yet to be demonstrated. Indeed, the function and signalling properties of Dock5 are poorly understood thus far. Dock5 has been identified as a crucial signalling protein in osteoclasts, and suppression of Dock5 expression with shRNA has been shown to inhibit survival and differentiation of osteoclast precursor cells. In addition, a mutation in Dock5 has been associated with the rupture of murine lens cataracts. In zebrafish Dock5 has been implicated in myoblast fusion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG185Hu01 Recombinant Dedicator Of Cytokinesis 5 (DOCK5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 5 (DOCK5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 5 (DOCK5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 5 (DOCK5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 5 (DOCK5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG185Mu01 Recombinant Dedicator Of Cytokinesis 5 (DOCK5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 5 (DOCK5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 5 (DOCK5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 5 (DOCK5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 5 (DOCK5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dedicator Of Cytokinesis 5 (DOCK5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 5 (DOCK5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 5 (DOCK5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 5 (DOCK5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 5 (DOCK5) ELISA Kit Customized Service Offer
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