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Forkhead Box Protein A1 (FOXA1)

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FOX-A1; HNF3A; Hepatocyte Nuclear Factor 3,alpha

Forkhead Box Protein A1 (FOXA1)
CCC G207
HGNC 5021
MGI 1347472
PubMed 24531377
RGD 2807
UniProt P55317
Wiki FOXA1
FOXA1 encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
The genes encode polypeptides of 468, 459, and 354 amino acids, respectively. Both HNF3A and HNF3B are expressed in tissues of endodermal origin, i.e., stomach, intestines, liver, and lung, while HNF3G is more extensively expressed, being present additionally in ovary, testis, heart, and adipose tissue, but missing from lung.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG207Hu01 Recombinant Forkhead Box Protein A1 (FOXA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG207Hu01 Polyclonal Antibody to Forkhead Box Protein A1 (FOXA1) WB; IHC; ICC; IP.
Assay Kits SEG207Hu ELISA Kit for Forkhead Box Protein A1 (FOXA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein A1 (FOXA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein A1 (FOXA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein A1 (FOXA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein A1 (FOXA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein A1 (FOXA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein A1 (FOXA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein A1 (FOXA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein A1 (FOXA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein A1 (FOXA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein A1 (FOXA1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line."Biochim. Biophys. Acta 1307:17-20(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis."Hum. Hered. 50:370-381(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas."Cancer Res. 62:5273-5279(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation."Development 132:3431-3443(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response."Proc. Natl. Acad. Sci. U.S.A. 102:11651-11656(2005) [PubMed] [Europe PMC] [Abstract]
  9. "BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1)."Oncogene 25:1391-1399(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells."Mol. Cell. Biol. 27:2155-2165(2007) [PubMed] [Europe PMC] [Abstract]
  11. "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription."Cell 132:958-970(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes."Cell Stress Chaperones 14:417-425(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq."Genome Biol. 10:R129.0-R129.0(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM."Mol. Cell. Biol. 30:399-412(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]