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Forkhead Box Protein F1 (FOXF1)

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FKHL5; FREAC1; FOX-F1; Forkhead-related activator 1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1

Forkhead Box Protein F1 (FOXF1)
CCC G219
HGNC 3809
MGI 1347470
PubMed 11493558
UniProt Q12946
Wiki FOXF1
FOXF1 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.The predicted 354-amino acid protein is nearly identical to FREAC2 (FKHL6) within a 112-residue region containing the forkhead domain and adjacent sequences, and within the C-terminal region. FREAC1/FREAC2 binding sequences are present in the promoters of several lung-specific genes, including CC10 and SPB (SFTPB). While both FREAC1 and FREAC2 transactivated an SPB promoter construct, CC10 was activated only by FREAC1. CC10 activation occurred specifically in a lung cell line with Clara cell-like characteristics.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein F1 (FOXF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein F1 (FOXF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein F1 (FOXF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein F1 (FOXF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein F1 (FOXF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG219Mu01 Recombinant Forkhead Box Protein F1 (FOXF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG219Mu01 Polyclonal Antibody to Forkhead Box Protein F1 (FOXF1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Forkhead Box Protein F1 (FOXF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein F1 (FOXF1) ELISA Kit Customized Service Offer
  1. "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2."J. Biol. Chem. 271:4482-4490(1996) [PubMed] [Europe PMC] [Abstract]
  2. "FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces."Dev. Biol. 202:183-195(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations." Am. J. Hum. Genet. 84:780-791(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain." Hum. Mutat. 34:801-811(2013) [PubMed] [Europe PMC] [Abstract]