Forkhead Box Protein F2 (FOXF2)

The forkhead domain is a 100-amino acid monomeric DNA binding motif originally identified as a region of homology between the Drosophila forkhead protein and rat HNF3. Northern blot analysis revealed that the FREAC2, or FKHL6, gene is expressed as a 2.4-kb mRNA primarily in placenta and adult and fetal lung. The predicted 408-amino acid protein is missing the N-terminal region.

Sequence analysis revealed that the FREAC1 (FKHL5) and FREAC2 proteins are nearly identical within a 112-residue region containing the forkhead domain and adjacent sequences, and within the C-terminal region.verexpression of TFIIB potentiates transcriptional activation by FREAC2, suggesting that FREAC2 regulates transcription, in part, through recruitment of TFIIB.