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Forkhead Box Protein L2 (FOXL2)

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FOX-L2; BPES; BPES1; PFRK; PINTO; POF3

Forkhead Box Protein L2 (FOXL2)
CCC G230
HGNC 1092
MGI 1349428
PubMed 19516027
RGD 1310041
UniProt P58012
Wiki FOXL2
FOXL2 is a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function.FOXL2 is involved in sex determination. Female missing the FOXL2 gene appear male. FOXL2 knockout in mature mouse ovaries cause them to develop into testes, however oocytes are still formed.
FOXL2, in the blepharophimosis/ptosis/epicanthus inversus syndrome (BPES; 110100) critical region on chromosome 3q23. Consistent with an involvement in BPES, FOXL2 was selectively expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles; in adult humans, it appeared predominantly in the ovary.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPG230Hu61 Eukaryotic Forkhead Box Protein L2 (FOXL2) Positive Control; Immunogen; SDS-PAGE; WB.
RPG230Hu01 Recombinant Forkhead Box Protein L2 (FOXL2) Positive Control; Immunogen; SDS-PAGE; WB.
APG230Hu61 Active Forkhead Box Protein L2 (FOXL2) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein L2 (FOXL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein L2 (FOXL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein L2 (FOXL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein L2 (FOXL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein L2 (FOXL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein L2 (FOXL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein L2 (FOXL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein L2 (FOXL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein L2 (FOXL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein L2 (FOXL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein L2 (FOXL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein L2 (FOXL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein L2 (FOXL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein L2 (FOXL2) ELISA Kit Customized Service Offer
  1. "The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome." Nat. Genet. 27:159-166(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis."Biochem. Biophys. Res. Commun. 336:876-881(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the steroidogenic acute regulatory gene."Cell. Signal. 21:1935-1944(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations."Hum. Mol. Genet. 18:632-644(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Functional evidence implicating FOXL2 in non-syndromic premature ovarian failure and in the regulation of the transcription factor OSR2."J. Med. Genet. 46:455-457(2009) [PubMed] [Europe PMC] [Abstract]
  7. "The human FOXL2 mutation database."Hum. Mutat. 24:189-193(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Spectrum of FOXL2 gene mutations in blepharophimosis-ptosis-epicanthus inversus (BPES) families demonstrates a genotype --phenotype correlation." Hum. Mol. Genet. 10:1591-1600(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in FOXL2 underlying BPES (types 1 and 2) in Colombian families."Am. J. Med. Genet. 113:47-51(2002) [PubMed] [Europe PMC] [Abstract]
  10. "FOXL2 mutation screening in a large panel of POF patients and XX males."J. Med. Genet. 39:E43-E43(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of novel mutations in FOXL2 associated with premature ovarian failure."Mol. Hum. Reprod. 8:729-733(2002) [PubMed] [Europe PMC] [Abstract]
  12. "FOXL2 and BPES: mutational hotspots, phenotypic variability, and revision of the genotype-phenotype correlation." Am. J. Hum. Genet. 72:478-487(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Sporadic and familial blepharophimosis -ptosis-epicanthus inversus syndrome: FOXL2 mutation screen and MRI study of the superior levator eyelid muscle."Clin. Genet. 63:117-120(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Comparative analysis of the FOXL2 gene and characterization of mutations in BPES patients."Hum. Mutat. 22:222-228(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Genetic analysis of a five generation Indian family with BPES: a novel missense mutation (p.Y215C)."Mol. Vis. 10:445-449(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Three novel FOXL2 gene mutations in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome."Chin. Med. J. 119:49-52(2006) [PubMed] [Europe PMC] [Abstract]
  17. "A novel polyalanine expansion in FOXL2: the first evidence for a recessive form of the blepharophimosis syndrome (BPES) associated with ovarian dysfunction."Hum. Genet. 121:107-112(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Missense mutations in the forkhead domain of FOXL2 lead to subcellular mislocalization, protein aggregation and impaired transactivation."Hum. Mol. Genet. 17:2030-2038(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Differential functional effects of novel mutations of the transcription factor FOXL2 in BPES patients."Hum. Mutat. 29:E123-E131(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Identification of 34 novel and 56 known FOXL2 mutations in patients with blepharophimosis syndrome." Hum. Mutat. 29:E205-E219(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Mutation of FOXL2 in granulosa-cell tumors of the ovary." N. Engl. J. Med. 360:2719-2729(2009) [PubMed] [Europe PMC] [Abstract]
  22. "The specificity of the FOXL2 c.402C>G Somatic mutation: a survey of solid tumors."PLoS ONE 4:E7988-E7988(2009) [PubMed] [Europe PMC] [Abstract]